Wellbutrin (bupropion) is an antidepressant medication. It works in the brain to treat depression.
Wellbutrin xl 300 mg online in the Netherlands from January 2002 to June 2006. The mean (±SD) age at first dose was 15.1 (8.1) years, and the mean (±SD) age at endpoint was 20.5 (2.5) years. There a trend towards higher proportion of female participants in the placebo arm (57.3%; 95% CI: 47.0–60.3%) than in the butrin/bupropion arm (47.7%; 95% CI: 33.5–53.8%; P=0.07). Discussion This is the first prospective study of an open-label combination bupropion/levonantradol plus bupropion in adults. We found that bupropion did not significantly improve depressive symptoms or functional impairment in the short term and that lorazepam was associated with a significantly greater impairment than the comparison placebo arm. The most important findings were that, in addition to improved mood, bupropion cognitive performance by improving verbal fluency and memory retention, while lorazepam deteriorated cognition. Although there were differences in the results based on different methods of assessing and reporting symptoms, these effects were comparable on the different instruments.12 Moreover, findings are consistent with previous small studies.13,24 Our results are in accordance with most small clinical trials in young adults, which bupropion alone appeared to improve cognitive performance and mood by similar magnitude as bupropion plus or placebo.13–23 However, most of these studies contained several methodological limitations, including small sample sizes, few patients, and a short open-label period lasting only 6 weeks. The results with bupropion alone are also difficult to interpret because of the relatively smaller sample sizes in these studies. It is possible that the cognitive deficits resulting from bupropion alone may be partly due to other adverse effects, such as hyponatremia.25 Nevertheless, the results with bupropion alone appear to indicate that bupropion offers a cognitive benefit, such that it should reduce symptoms of depression and improve cognitive performance. This conclusion is supported by several studies in which either bupropion alone or the combination of bupropion and lorazepam have been shown to improve cognitive performance, but not necessarily mood.26 Studies also show that the combination of bupropion and lorazapam also improved canada pharmacy free shipping coupon code mood.27 The finding that citalopram was associated with a higher cognitive impairment than lorazepam supports previous small clinical trials that found the combination of citalopram and lorazepam was associated with increased risk of cognitive impairment.28,29 It also emphasizes the importance of monitoring duration bupropion therapy, because the risk of cognitive impairment for bupropion is more likely when dosing reduced than is increased.30 In the placebo arm, lorazepam appears to have significantly greater impairment than lorazepam and placebo. The reason for this is unclear, although it could be due to the fact that lorazepam reduces citalopram's antidepressant effect or due to the fact that citalopram is not used long enough to yield a reliable cognitive.
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